High Sensitive C-Reactive Protein and Lipid Profile Alteration In Subclinical Hypothyroidism for Cardiovascular Risk Assessment

Smrity  Rajkarnikar; Vijay Kumar  Sharma; Sujata  Baidya; Pratibha  Kadel; Eans Tara  Tuladhar; Apeksha  Niraula; Aseem  Bhattarai; Mithileshwer  Raut; Raju Kumar  Dubey; Naresh  Parajuli

doi:10.33314/jnhrc.v22i02.5383

Smrity Rajkarnikar Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Vijay Kumar Sharma Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Sujata Baidya Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Pratibha Kadel Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Eans Tara Tuladhar Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Apeksha Niraula Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Aseem Bhattarai Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Mithileshwer Raut Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Raju Kumar Dubey Department of Clinical Biochemistry, Maharajgunj Medical Campus, Institute of Medicine,Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Naresh Parajuli Department of Internal Medicine (Endocrinology), Maharajgunj Medical Campus, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal

DOI: https://doi.org/10.33314/jnhrc.v22i02.5383

Abstract

Background: The purpose of this study was to investigate the association of subclinical hypothyroidism with High sensitive C-reactive protein & lipid profile which can predispose to development of Cardiovascular disease.
Methods: This hospital-based comparative cross-sectional study was conducted for a period of six months. A total of 71 patients with subclinical hypothyroidism & 37 healthy control subjects were enrolled for the study. Thyroid hormones, lipid profile, hs- CRP were measured and lipid variables were used to calculate lipid indices. Student t-test were used to compare means & Spearmanâ€™s correlation was done to determine the association between variables. ROC curve analysis was used to determine the diagnostic value of tests.
Results: Out of 71 cases & 37 control, majority had female preponderance (71.8% in case & 83.8% in control). The mean values between case & control groups for hs-CRP, AIP, LCI and non-HDL cholesterol were statistically significant. There was positive correlation between TSH and hs-CRP (r=0.492, p <0.001), AIP and TSH (r=0.430, p<0.001), LCI and TSH (r=0.269, p =0.005), TSH and non-HDL cholesterol (r=0.308, p=0.001) & AI and LDL (r= 0.712, p<0.001) with weak correlation with statistical significance as per Spearmanâ€™s correlation. Area under ROC curve for hs-CRP indicated it as a positive biomarker for CVD assessment.
Conclusions: Our findings shows that SCH patients are more at risk of CVD & hs-CRP contributes as a significant marker, thus requiring timely intervention. Lipid indices and AIP must be determined even in patients with a normal lipid profile to improve atherogenic risk.
Keywords: Cardiovascular risk; dyslipidemia; hs-CRP; subclinical hypothyroidism.