Serum Vitamin B12 Level in Children with Type 1 Diabetes

  • Santosh Pradhan Department of Biochemistry, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
  • Subhana Thapa Department of Internal Medicine, Kanti Childrens Hospital, Kathmandu, Nepal.
  • Pradeep Krishna Shrestha Department of Internal Medicine, Tribhuvan University Teaching Hospital, Kathmandu, Nepal.
  • Bharat Jha Department of Biochemistry, Tribhuvan University Teaching Hospital, Kathmandu, Nepal
DOI: https://doi.org/10.33314/jnhrc.v23i01.4726

Abstract

Background: Type 1 Diabetes Mellitus is known to be associated with multiple co-morbidities. Vitamin B12 deficiency is a potential co- morbidity that might have been overlooked in these patients. The aim of this study is to evaluate the serum level of vitamin B 12 in a well-defined population of Type 1 diabetes.

Methods: The cross sectional study carried out on 40 patients with Type 1 Diabetes Mellitus visiting endocrinology unit in Kanti children’s Hospital, Kathmandu, Nepal. Thirty healthy non diabetics were also selected. Serum C-peptide, vitamin B12, creatinine, blood glucose level and glycosylated hemoglobin were assessed in both groups. SPSS ver. 22 was used to analyze the data.

Results:The mean serum vitamin B12 level of the diabetic group was 206.92±82.18 pmol/L. Among the population 40.0% i.e. 16 out of 40 were found to be deficient and 37.5 % i.e. 15 out of 40 were subclinically deficient. Whereas the mean serum vitamin B12 level of the non diabetic group was 340.71±136.02pmol/L. Out of 30 only 2(6.7%) were deficient, 8 (26.75%) were found to be subclinically deficient. Significant difference was noticed in the mean serum level of vitaminB12 between these two groups.

Conclusions: This study shows the presence of low serum vitamin B12 levels in Type 1 Diabetics. The routine screening for this condition along with confirmatory test and detail clinical examination could benefit the patients with Type 1 diabetes.

Keywords: Autoimmune disease; Type 1 Diabetes mellitus; Vitamin B12.

Published
2025-06-29
How to Cite
Pradhan, S., Thapa, S., Shrestha, P. K., & Jha, B. (2025). Serum Vitamin B12 Level in Children with Type 1 Diabetes. Journal of Nepal Health Research Council, 23(01), 14-20. https://doi.org/10.33314/jnhrc.v23i01.4726
Issue
Vol. 23 No. 01 (2025): Issue 66 Jan-March, 2025
Section
Original Article

Copyright (c) 2025 Santosh Pradhan, Subhana Thapa, Pradeep Krishna Shrestha, Bharat Jha

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